Gerard Karsenty received his M.D. and Ph.D. from the University of Paris, France and completed his post-doctoral training at the University of Texas MD Anderson Cancer Center in 1990. His laboratory has studied every aspect of skeletal biology ranging from cell differentiation to function. The overarching assumption of his current work is that the appearance of bone during evolution has changed profoundly the physiology of animals because of the energetic cost that bone modeling and remodeling entails. Thus his group has explored in the last 10 years the hypothesis that the control of bone mass and energy metabolism must be coordinated and that this coordination is done in large part by hormones like leptin and osteocalcin that appear during evolution with bone. His lab has explored through genetic and molecular means every aspect of this hypothesis. At the same time a expanding his research the Karsenty lab is exploring whether there are additional connections between bone physiology and the function of other organs such as fertility. Dr. Karsenty is the recipient of several awards.