Pamela Silver received her BS in Chemistry and PhD in Biochemistry from the University of California where she was an NIH Pre-doctoral Fellow. She was a Postdoctoral Fellow at Harvard University where she was a Fellow of the American Cancer Society and The Medical Foundation. Subsequently, she was an Assistant Professor in the Dept of Molecular Biology at Princeton University where she was an Established Investigator of the American Heart Association, a Research Scholar of the March of Dimes and was awarded an NSF Presidential Young Investigator Award. She moved to Harvard Medical School where she was a Professor in the Dept of Biological Chemistry and Molecular Pharmacology. She was named a Claudia Adams Barr Investigator and awarded the Mentoring Award for the PhD Program in Biological and Biomedical Sciences at Harvard Medical School. In 2004, she became one of the first members of the Department of Systems Biology at Harvard Medical School and the first Director of the Harvard University PhD Program in Systems Biology. In 2009, she became one of the first members of the Harvard University Wyss Institute for Biologically Inspired Engineering. Her work was recognized by an Innovation Award at BIO2007 and has been funded by grants from the NIH, DOD, DOE, NSF, Novartis, Merck and The Keck Foundation. She currently holds an NIH MERIT award. She has served on numerous government and private advisory panels including the NIH Pioneer and Innovator Award Committees, the NAS/NRC Study on Network Science, the OSD/NA Biodefense Workshop, the Jane Coffin Childs Memorial Fund, the Novartis Oncology Program and the Institute of Synthetic Biology at Imperial College.  Her laboratory works in diverse areas of Systems and Synthetic Biology.  The main focus areas include predictable design of biological systems and designing sustainability.