Pamela Silver is a Professor of Systems Biology at Harvard Medical School. She received her PhD in Biochemistry from the University of California. She was a Postdoctoral Fellow at Harvard University where she was a Fellow of the American Cancer Society and The Medical Foundation. Subsequently, she was an Assistant Professor in the Dept of Molecular Biology at Princeton University where she was an Established Investigator of the American Heart Association, a Research Scholar of the March of Dimes and was awarded an NSF Presidential Young Investigator Award. She moved to the Dana Farber Cancer Institute where she was a Professor in the Dept of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. She was named a Claudia Adams Barr Investigator and awarded the Mentoring Award for the PhD Program in Biological and Biomedical Sciences at Harvard Medical School. In 2004, she became one of the first members of the Department of Systems Biology at Harvard Medical School and the first Director of the Harvard University PhD Program in Systems Biology. In 2009, she became one of the founding members of the Harvard University Wyss Institute for Biologically Inspired Engineering. Her laboratory works in diverse areas of Systems and Synthetic Biology. The main focus areas include the connections between the nucleus and the cytoplasm in disease states that lead to potential therapeutics, predictable design of genetic circuits, and designing sustainability and mutualism.